検索結果

Search Results for " nuclear translocation "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T6207	SC144		Apoptosis , Interleukin
	SC144 is an orally active small-molecule gp130 inhibitor.		Apoptosis , Interleukin
T28362	PF-02413873	PF02413873	Progesterone Receptor
	PF-02413873 is a competitive antagonist of nonsteroidal progesterone receptor with a Ki of 2.6 nM. PF-02413873 can be used in studies about the treatment of gynecological conditions such as endometriosis.		Progesterone Receptor
T8730	BMS986260		TGF-beta/Smad
	BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).		TGF-beta/Smad
T83727	Tat-NTS Peptide TFA	Tat-Nuclear Translocation Signal Peptide
	Tat-NTS peptide, a cell-penetrating compound, comprises the HIV-1 Tat protein transduction domain fused with a 10-amino acid sequence (residues 228-237) from the repeat III domain of annexin A1, serving as a nuclear tran...
T2008	LY294002	LY 294002,NSC 697286,SF 1101	Apoptosis , DNA-PK , Casein Kinase , PI3K , Autophagy
	LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 ...		Apoptosis , DNA-PK , Casein Kinase , PI3K , Autophagy
T4079	LY-294002 hydrochloride	SF 1101,LY 294002,NSC 697286	PI3K
	LY-294002 hydrochloride (NSC 697286) is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation...		PI3K
T11886	LTβR-IN-1		Others , NF-κB , LTR
	LTβR-IN-1 is a potent and selective lymphin β receptor (LTβR) inhibitor. LTβR-IN-1 has a selective inhibitory effect on the nuclear translocation of p52 of TNF12A, and has no obvious effect on the nuclear translocation o...		Others , NF-κB , LTR
T6915	Darolutamide	ODM-201,BAY-1841788	Androgen Receptor
	Darolutamide (BAY-1841788) is an androgen receptor (AR) antagonist that blocks AR nuclear translocation (Ki: 11 nM).		Androgen Receptor
T4657	WHI-P97		JAK
	WHI-P97 is a rationally designed potent inhibitor of JAK-3. IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane ...		JAK
T4022	QS11	QS 11	GTPase
	QS11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also r...		GTPase
T6308	Stattic	STAT3 Inhibitor V	Apoptosis , STAT
	Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 μM) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation. Stattic has antitumor activity and induces apoptosis.		Apoptosis , STAT
T61531	NFATc1-IN-1		RANKL/RANK
	NFATc1-IN-1 (also known as compound A04) is a highly effective inhibitor of osteoclast formation induced by RANKL, with an IC50 of 1.57 μM. It exerts its anti-osteoclastogenic effects by attenuating the RANKL-induced nuc...		RANKL/RANK
T11760	KIN101	3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene	HCV Protease , Influenza Virus , RSV , Antifection
	KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene), an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and R...		HCV Protease , Influenza Virus , RSV , Antifection
TP1938L	RS09 2TFA (1449566-36-2 free base)	RS09 2TFA 1449566-36-2(free base)	TLR
	RS09 2TFA (1449566-36-2 free base) is a TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. It acts as an adjuvant in vivo and enhances X-15 sp...		TLR
T77332	TV 3279		BCL , PKC
	TV 3279 is a novel ChE-MAI inhibitor , and the neuroprotective properties depend on their ability to induce the anti-apoptotic proteins PKC, Bcl-2, Bcl-x, and SOD, and to block the nuclear translocation of the pro-apopto...		BCL , PKC
T19710	Ciglitazone	Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878	Apoptosis , p38 MAPK , PPAR
	Ciglitazone (ADD 3878) is a potent and selective PPARγ agonist (EC50: 3 μM) and oral hypoglycemic agent. Ciglitazone inhibits proliferation and differentiation of th17 cells, decreases insulin levels, vascular endothelia...		Apoptosis , p38 MAPK , PPAR
T8055	TFEB activator 1	(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,,Curcumin analog compound C1,Curcumin analog C1,RPN77612	Others , Autophagy
	TFEB activator 1 (Curcumin analog compound C1) is an activator of transcription factor EB (TFEB) with promise for the prevention or treatment of Alzheimer's disease.		Others , Autophagy
T60013	GA-017		Others
	GA-017 is a potent, selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 1/2), exhibiting IC50 values of 4.10 and 3.92 nM, respectively. This compound simultaneously acts as an activator of cell prolifer...		Others
T6964	Resiquimod	R848,S28463	HCV Protease , TLR
	Resiquimod (R848) is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect through the TLR signaling pathway by binding to and acti...		HCV Protease , TLR
T71842	D719
	D719 is a novel inhibitor of integrase nuclear translocation, showing significant inhibition on virus p24 antigen production.
T30868	CH-5137291	CH 5137291,CH5137291
	CH-5137291 is a pure AR antagonist with AR nuclear translocation inhibition activity. It suppresses castration and prevents the growth of prostate cancer cells.
T30877	CHF-1024	UNII-HPH2L3QA2F
	CH-5137291 is a pure AR antagonist with AR nuclear translocation inhibition activity. It inhibits castration and prevents the growth of prostate cancer cells.
T68986	ZINC08383544
	ZINC08383544 is a specific pyruvate kinase M2 activator which promotes the formation of PKM2 tetramer. ZINC08383544 effectively blocks PKM2 nuclear translocation, and inhibits the growth of tumor.
T36535	SEC
	SEC activates ANXA7 GTPase through the AMPK/mTORC1/STAT3 signaling pathway. It selectively induces apoptosis in cancer cells expressing high levels of ITGB4 by promoting ITGB4 nuclear translocation [1][2].
T26936	C188	Cpd188,STAT3-IN-C188,Cpd-188,C 188,C-188
	C188 is a cell-permeable naphthol compound and a STAT3 inhibitor. C188 inhibits IL-6-stimulated STAT3 Tyr705 phosphorylation and nuclear translocation in HepG2 cells by targeting STAT3 SH2 domain peptide-binding pocket, ...
T38460	SN52
	SN52 is a powerful, competitive, and cell-permeable inhibitor of NF-κB2. It is a variant of the SN50 peptide. SN52 effectively prevents the nuclear translocation of p52-RelB heterodimers, exhibiting a robust radiosensiti...
TP1938	RS 09		TLR
	TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enhances X-15 specific antibody serum concentrations, when adm...		TLR
T70399	TTC-352
	TTC-352 is an orally bioavailable selective human estrogen receptor alpha (ERalpha; ESR1; ERa) partial agonist (ShERPA), with potential antineoplastic activity. Upon administration, TTC-352 mimics the naturally-occurring...
TP2157L	TAT-DEF-Elk-1 TFA (1220751-16-5 free base)	TDE TFA,TAT-DEF-Elk-1 TFA	Others
	TAT-DEF-Elk-1 TFA is a cell-penetrating peptide Elk-1 inhibitor, mimics and specifically interferes with the DEF domain of Elk-1. TAT-DEF-Elk-1 blocks Elk-1 phosphorylation and prevents Elk-1 nuclear translocation withou...		Others
T35429	AC-4-130
	AC-4-130, a powerful inhibitor of the SH2 domain of STAT5, effectively hinders STAT5 activation, dimerization, nuclear translocation, and transcription of genes reliant on STAT5. This compound directly binds to STAT5, ul...
T83047	Anti-inflammatory agent 65		STING
	Anti-inflammatory agent 65 (compound 29), a Hederagonic acid derivative, exhibits potent activity by inhibiting nitric oxide (NO) release, nuclear translocation of IRF3 and p65, and disrupting the STING/IRF3/NF-κB signal...		STING
T78846	EP12		Apoptosis
	EP12, a c-Myc inhibitor and G4 stabilizer, induces apoptosis and DNA damage in multiple myeloma cells while obstructing P65/P50 nuclear translocation by disrupting the NF-κB signaling pathway, effectively inhibiting mult...		Apoptosis
T78640	Z-LLF-CHO	Z-Leu-Leu-Phe-CHO	Proteasome
	Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) effectively inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex with a Ki value of 460 nM. Additionally, this compound serves as an inhibitor of NF-κB ...		Proteasome
T79465	Anticancer agent 135		Androgen Receptor
	Anticancer agent 135 (compound 26h) acts as a potent androgen receptor (AR) antagonist, effectively blocking AR nuclear translocation and inhibiting AR/AR-V7 heterodimerization to suppress downstream gene transcription. ...		Androgen Receptor
T69401	MIND4-17
	MIND4-17, a potent NRF2 activator, covalently modifies the C151 residue of Keap1, disrupting the Keap1-Nrf2 association. This action leads to the stabilization and nuclear translocation of the Nrf2 protein, consequently ...
T68393	SNX-7081
	NX-7081 is a novel small molecule inhibitor of Hsp90, which blocks components of inflammation, including cytokine production, protein kinase activity, and angiogenic signaling. SNX-7081 showed strong binding affinity to ...
T60988	Androgen receptor antagonist 4
	Androgen receptor antagonist 4 (Compound AT2) has anticancer activities. Androgen receptor antagonist 4 potently antagonizes the activity of AR transcriptional, inhibits downstream target gene of AR, and blocks the DHT-i...
T71361	CHS-828 nicotinate
	CHS-828 nicotinate is a CHS-828 salt with Nicotinic acid.. CHS-828 also known as GMX-1778, is a potent and selective NAMPT inhibitor. CHS-828 inhibits cellular synthesis of NAD. CHS 828 kill tumour cells by inhibiting ...
T75952	RS 09 TFA
	RS 09 TFA, a TLR4 agonist, promotes NF-κB nuclear translocation and induces the secretion of inflammatory cytokines in RAW264.7 macrophages in vitro. Additionally, as an adjuvant in vivo, RS 09 TFA enhances serum concent...
T5339	YZ129
	YZ129, a glioblastoma inhibitor, targets the HSP90-calcineurin-NFAT pathway by directly binding to heat shock protein 90 (HSP90) and exhibits an IC 50 of 820 nM on NFAT nuclear translocation. It induces cell-cycle arrest...
T72687	Keap1-Nrf2-IN-11
	Keap1-Nrf2-IN-11 (Compound 6k), a potent Keap1-Nrf2 inhibitor, exhibits a dissociation constant (KD) of 0.21 nM. It hampers the production of reactive oxygen species (ROS) and nitric oxide (NO), as well as the expression...
T78716	MKA031
	MKA031 (compound 6y) is a non-competitive inhibitor of macrophage migration inhibitory factor (MIF), exhibiting an IC50 of 1.7 μM. It disrupts the MIF-aryl hydrocarbon receptor interacting protein (AIF) interaction, impe...
T62111	Antioxidant agent-5
	Antioxidant agent-5 (compound D-6) is a potent antioxidant. antioxidant agent-5 inhibits oxLDL-induced increases in ROS levels and NF-κB nuclear translocation. antioxidant agent-5 inhibits oxLDL (oxidized LDL)-induced ap...
T41260	SC144 hydrochloride
	SC144 hydrochloride, a first-in-class, orally active, small-molecule gp130 (IL6-beta) inhibitor, demonstrates potent inhibition of gp130 ligand-triggered signaling. By binding to gp130, it initiates gp130 phosphorylation...
T79662	STAT3-IN-20		STAT
	STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclear translocation, and subsequent gene transcription. The compound...		STAT
T69288	CEP-7055
	CEP-18770 is an orally bioavailable synthetic P2 threonine boronic acid inhibitor of the chymotrypsin-like activity of the proteasome, with potential antineoplastic activity. Proteasome inhibitor CEP 18770 represses the ...
T36645	CAY10763	CAY10763
	CAY10763 is a dual inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50= 46 nM) and STAT3 activation.1It binds to STAT3 (Kd= 530 nM) and selectively reduces the levels of STAT3 phosphorylated at the tyrosine in position...
T81038	TAT-DEF-Elk-1 TFA	TDE TFA
	TAT-DEF-Elk-1 TFA (TDE TFA) is a cell-penetrating peptide that inhibits Elk-1 by mimicking its DEF domain and disrupting its function. It effectively blocks Elk-1 phosphorylation and its subsequent nuclear translocation,...
T83661	17(R,S)-Benzo-Resolvin D1	17(R,S)-Benzo-RvD1,Benzo-RvD1
	Benzo-resolvin D1 (benzo-RvD1), a derivative of the specialized pro-resolving mediator (SPM) RvD1, effectively reduces PDGF-BB-induced cytoskeletal alterations and PDGF-triggered migration in isolated human vascular smoo...
T78698	Aβ-IN-6
	Aβ-IN-6 is an orally active compound exhibiting anti-inflammatory, antioxidant, and anti-oligomeric activities, with significant implications for Alzheimer's disease (AD) research [1]. It effectively reduces the release ...

Compounds

SC144

T6207

Synonym:

Target: Apoptosis, Interleukin

PF-02413873

T28362

Synonym: PF02413873

Target: Progesterone Receptor

BMS986260

T8730

Synonym:

Target: TGF-beta/Smad

Tat-NTS Peptide TFA

T83727

Synonym: Tat-Nuclear Translocation Signal Peptide

Target:

LY294002

T2008

Synonym: LY 294002,NSC 697286,SF 1101

Target: Apoptosis, DNA-PK, Casein Kinase, PI3K, Autophagy

LY-294002 hydrochloride

T4079

Synonym: SF 1101,LY 294002,NSC 697286

Target: Others, NF-κB, LTR

Darolutamide

T6915

Synonym: ODM-201,BAY-1841788

Target: Androgen Receptor

Synonym: STAT3 Inhibitor V

Target: Apoptosis, STAT

Synonym: 3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene

Target: HCV Protease, Influenza Virus, RSV, Antifection

RS09 2TFA (1449566-36-2 free base)

TP1938L

Synonym: RS09 2TFA 1449566-36-2(free base)

Synonym: Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878

Target: Apoptosis, p38 MAPK, PPAR

TFEB activator 1

T8055

Synonym: (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,,Curcumin analog compound C1,Curcumin analog C1,RPN77612

Target: Others, Autophagy

Target: HCV Protease, TLR

Synonym: CH 5137291,CH5137291

Target:

CHF-1024

T30877

Synonym: UNII-HPH2L3QA2F

Synonym: Cpd188,STAT3-IN-C188,Cpd-188,C 188,C-188

TAT-DEF-Elk-1 TFA (1220751-16-5 free base)

TP2157L

Synonym: TDE TFA,TAT-DEF-Elk-1 TFA

Anti-inflammatory agent 65

Synonym: Z-Leu-Leu-Phe-CHO

Target: Androgen Receptor

Androgen receptor antagonist 4

17(R,S)-Benzo-Resolvin D1

T83661

Synonym: 17(R,S)-Benzo-RvD1,Benzo-RvD1

カタログ番号	製品名	別名	ターゲット
T5689	20-DEOXYINGENOL		Others , Autophagy
	20-DEOXYINGENOL is a natual product.		Others , Autophagy
T19768	γ-Tocotrienol	gamma Tocotrienol,gammaTocotrienol,gamma-Tocotrienol,D-gamma-Tocotrienol,Plastochromanol	Others
	γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E. Itl is also a radioprotector, antioxidant. It shows antitumor and antihypertensive effects in vivo.		Others
T5701	OPHIOPOGONIN D		RAAS , Calcium Channel , NF-κB , PPAR
	Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.		RAAS , Calcium Channel , NF-κB , PPAR
T4237	Rubiadin-1-methyl ether	Rubiadin 1-methyl ether	Anti-infection , NF-κB
	Rubiadin-1-methyl ether (Rubiadin 1-methyl ether) is a natural product.It inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nu...		Anti-infection , NF-κB
T2836	Isorhamnetin	3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin	MEK , PI3K , Endogenous Metabolite
	Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LD...		MEK , PI3K , Endogenous Metabolite
T0798	Triamcinolone	Fluoxyprednisolone,Aristocort,Rodinolone	Glucocorticoid Receptor , COX
	Triamcinolone (Aristocort) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and activates the glucocorticoid receptor, which leads to transloca...		Glucocorticoid Receptor , COX
TMA0237	Carlinoside		Nrf2
	Carlinoside could be a worthy choice to intervene hyperbilirubinemia due to liver dysfunction. Carlinoside upregulates Nrf2 gene expression, increases its nuclear translocation and stimulates UGT1A1 promoter activity.		Nrf2
TN6394	Alisol B acetate
	Alisol B acetate can induce Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells, the Bax activation and translocation from the cytosol to nucleus might be a crucial response to t...
TN2178	Sanggenone H		IL Receptor , TNF , NF-κB
	Sanggenone H may have antiphlogistic activity, it attenuated the secretion of TNF-α± and IL-1α² and inhibited the NF-κB nuclear translocation in LPS-stimulated macrophages.		IL Receptor , TNF , NF-κB
T40611	(E)-Dehydrodiconiferyl alcohol
	(E)-Dehydrodiconiferyl alcohol is a potent dual inhibitor of hCA IX and hCA XII, effectively impeding the catalytic activity of both carbonic anhydrase isoforms. Additionally, (E)-Dehydrodiconiferyl alcohol exerts inhibi...
TN1009	Epimagnolin B		NF-κB , NO Synthase , Prostaglandin Receptor
	Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the suppression of I-kappaB-alpha degradation and nuclear transl...		NF-κB , NO Synthase , Prostaglandin Receptor
TN4635	Neoechinulin A		NADPH-oxidase , Beta Amyloid , ASK , IκB/IKK , p38 MAPK , TNF , NOS , NF-κB , COX , Prostaglandin Receptor
	Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-ÎºB and p38 MAPK pathways, it may block the phosphorylation of mitogen-activated protein kinase (MAPK) ...

天然物製品

20-DEOXYINGENOL

T5689

Synonym:

Target: Others, Autophagy

γ-Tocotrienol

T19768

Synonym: gamma Tocotrienol,gammaTocotrienol,gamma-Tocotrienol,D-gamma-Tocotrienol,Plastochromanol

Target: RAAS, Calcium Channel, NF-κB, PPAR

Rubiadin-1-methyl ether

T4237

Synonym: Rubiadin 1-methyl ether

Target: Anti-infection, NF-κB

Isorhamnetin

T2836

Synonym: 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin

Target: MEK, PI3K, Endogenous Metabolite

Triamcinolone

T0798

Synonym: Fluoxyprednisolone,Aristocort,Rodinolone

Target: Glucocorticoid Receptor, COX

Target: IL Receptor, TNF, NF-κB

(E)-Dehydrodiconiferyl alcohol

Target: NF-κB, NO Synthase, Prostaglandin Receptor

Neoechinulin A

TN4635

Synonym:

Target: NADPH-oxidase, Beta Amyloid, ASK, IκB/IKK, p38 MAPK, TNF, NOS, NF-κB, COX, Prostaglandin Receptor

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-00376	IL-17RD Protein, Human, Recombinant (hFc)	Human	Human Cells
	Interleukin-17 receptor D (IL-17 RD), also known as SEF (similar expression to FGFs), is a type I transmembrane protein that is found in both the cytoplasm and plasma membrane. IL-17RD functions as a feedback inhibitor o...
TMPH-01521	HIV-2 (subtype A, isolate BEN) Protein Vpx (His)	HIV-2	E. coli
	Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by...
TMPH-02472	14-3-3 beta/alpha Protein, Mouse, Recombinant (His)	Mouse	Yeast
	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine moti...
TMPH-01522	HIV-2 (subtype A, isolate ROD) Protein Vpx (His)	HIV-2	Yeast
	Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by...
TMPH-02471	14-3-3 beta/alpha Protein, Mouse, Recombinant (E. coli, His)	Mouse	E. coli
	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine moti...
TMPH-03509	Simian immunodeficiency virus (SIV) (isolate PBj14/BCL-3) Vpx Protein (His & SUMO)	SIV	E. coli
	Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by...
TMPY-02964	Calcineurin B/PPP3R1 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	PPP3R1 belongs to the calcineurin regulatory subunit family. It is a regulatory subunit of calcineurin. Calcineurin is composed of two subunits: calcineurin A (CnA) and calcineurin B (CnB). Dephosphorylation of the nucle...
TMPY-04421	FES Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Proto-oncogene tyrosine-protein kinase Fes/Fps, also known as Proto-oncogene c-Fes, Proto-oncogene c-Fps, Feline sarcoma oncogene, FES and FPS, is a protein which contains oneFCH domain, oneprotein kinase domain and o...
TMPH-02392	Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) Nucleoprotein/NP Protein	LASV	E. coli
	Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host...
TMPH-02391	Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) Nucleoprotein/NP Protein (His & SUMO)	LASV	E. coli
	Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host...
TMPJ-01087	TIM14 Protein, S. cerevisiae, Recombinant	S. cerevisiae	E. coli
	Mitochondrial import inner membrane translocase subunit TIM14 (TIM14) is an essential component of the PAM complex. PAM complex is required for the translocation of transit peptide-containing proteins from the inner memb...
TMPH-02366	Junin mammarenavirus (JUNV) Nucleoprotein/NP Protein (His & SUMO)	JUNV	E. coli
	Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host...
TMPH-00543	Epstein-Barr virus (strain Raji) LMP1 Protein (His & SUMO)	EBV	E. coli
	Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several s...
TMPH-00542	Epstein-Barr virus (strain Raji) LMP1 Protein (His)	EBV	Yeast
	Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several s...
TMPH-00541	Epstein-Barr virus (strain AG876) LMP1 Protein (His & Myc)	EBV	E. coli
	Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several s...
TMPY-03500	ARL2BP Protein, Human, Recombinant (His)	Human	E. coli
	ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. ARL2BP binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activ...
TMPH-01359	CCND1 Protein, Human, Recombinant (His)	Human	E. coli
	Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylat...
TMPJ-00271	SMAD3 Protein, Human, Recombinant (His & Flag)	Human	E. coli
	Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so...
TMPY-01925	Nucleophosmin Protein, Human, Recombinant (His)	Human	E. coli
	Nucleophosmin 1 (NPM1), also known as nucleolar phosphoprotein B23 or numatrin, is a member of the nucleoplasmin family. Nucleophosmin (NPM) is a nucleolar phosphoprotein that plays multiple roles in ribosome assembly an...
TMPY-04259	Nucleophosmin Protein, Human, Recombinant (aa 2-294, His)	Human	E. coli
	Nucleophosmin 1 (NPM1), also known as nucleolar phosphoprotein B23 or numatrin, is a member of the nucleoplasmin family. Nucleophosmin (NPM) is a nucleolar phosphoprotein that plays multiple roles in ribosome assembly an...
TMPJ-00427	LAIR1 Protein, Rhesus macaque, Recombinant (His)	Rhesus Macaque	Human Cells
	Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) is a single-pass type I membrane protein. LAIR1 expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells...
TMPJ-00936	CCND2 Protein, Human, Recombinant (His)	Human	E. coli
	CCND2，also known as G1/S-specific cyclin-D2，is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each ...
TMPH-01246	POLR3A Protein, Human, Recombinant (His)	Human	E. coli
	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs,...
TMPH-01535	INSIG2 Protein, Human, Recombinant (His & Myc)	Human	in vitro E. coli expression system
	Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol...
TMPJ-00179	LAIR1 Protein, Human, Recombinant (aa 22-163, His & Avi), Biotinylated	Human	Human Cells
	Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) is a single-pass type I membrane protein. LAIR1 expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells...
TMPY-00625	IL-17RD Protein, Canine, Recombinant (His)	Canine	HEK293
	Interleukin-17 receptor D (IL-17D) also known as Interleukin-17 receptor-like protein, is a member of the interleukine-17 receptor family. IL-17RD functions as a feedback inhibitor of fibroblast growth factor-mediated Ra...
TMPY-00338	IL-17RD Protein, Canine, Recombinant (hFc)	Canine	HEK293
	Interleukin-17 receptor D (IL-17D) also known as Interleukin-17 receptor-like protein, is a member of the interleukine-17 receptor family. IL-17RD functions as a feedback inhibitor of fibroblast growth factor-mediated Ra...
TMPY-00844	IL-17RD Protein, Human, Recombinant (His)	Human	HEK293
	Interleukin-17 receptor D (IL-17D) also known as Interleukin-17 receptor-like protein, is a member of the interleukine-17 receptor family. IL-17RD functions as a feedback inhibitor of fibroblast growth factor-mediated Ra...
TMPH-03494	IFN gamma Protein, Sheep, Recombinant (E. coli, His)	Sheep	E. coli
	Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentatio...
TMPH-00775	IFN gamma Protein, Goat, Recombinant (His & Myc)	Goat	E. coli
	Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentatio...
TMPH-03495	IFN gamma Protein, Sheep, Recombinant (His)	Sheep	Yeast
	Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentatio...
TMPH-01268	SIAH1 Protein, Human, Recombinant (GST)	Human	E. coli
	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester...
TMPH-03764	YAP1 Protein, Human, Recombinant (His)	Human	Yeast
	Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor su...
TMPH-01860	PCK1 Protein, Human, Recombinant (His)	Human	E. coli
	Cytosolic phosphoenolpyruvate carboxykinase that catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) and acts as the rate-limiting enzyme in gluconeogenesis. Regulates cataplerosis and anap...
TMPY-00975	FSTL3 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Follistatin-like 3 (FLRG/Fstl3) is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. FLRG/Fstl3 is a recently described member of the FST family having an overall str...
TMPY-04456	PKC nu Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	Serine/threonine-protein kinase D3, also known as Protein kinase C nu type, Protein kinase EPK2, PRKD3, EPK2 and PRKCN, is a cytoplasm and membrane protein that belongs to the protein kinase superfamily, CAMK Ser/Thr pro...
TMPH-02521	PYCARD Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mit...
TMPH-01502	Humanin Protein, Human, Recombinant (GST)	Human	E. coli
	Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective e...
TMPH-01503	Humanin Protein, Human, Recombinant (hFc)	Human	HEK293
	Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective e...
TMPH-01606	BAG6 Protein, Human, Recombinant (His & Myc)	Human	Baculovirus
	ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which main...
TMPH-01605	BAG6 Protein, Human, Recombinant (E. coli, His & Myc)	Human	E. coli
	ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which main...